SUZANNE GAZDA M.D.
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Scientifically Speaking

Is there an autoimmune component to Parkinson’s disease?

8/3/2021

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The trajectory of a Parkinson’s diagnosis is progressive and chronic, typically beginning with what may be a tremor or mild symptoms of reduced mobility and potentially developing into a debilitating disorder that impacts many functions and organs. 

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What is the significance of folate deficiency and autism?

2/17/2021

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Research is revealing that a number of pediatric patients with autism reflect low folate in their brains and that this “cerebral folate deficiency (CFD) may be treatable with certain medications, specifically d,l-leucovorin calcium (also known as folinic acid). ​

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The dysregulated immune system response – when neural signaling goes awry.

1/4/2021

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What if we could better understand the immune response mechanisms behind the initiation of numerous neurological conditions - and subsequently be in a position to more effectively diagnose and treat these diseases?

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Is there a link between MS, Crohn’s and other autoimmune disease?

11/24/2020

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The co-occurrence of autoimmune diseases has been epidemiologically studied and has aided in our understanding of autoimmunity. Environmental triggers in genetically susceptible individuals are believed to cause disorders of immune regulation. Cytomegalovirus, for instance, is shown to cause the development of multiple autoantibodies.

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Alpha-synuclein in neurodegenerative disease.

10/7/2020

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The SNCA gene provides instructions for making a small protein called alpha-synuclein. Alpha-synuclein is abundant in the brain, and smaller amounts are found in the heart, muscles, and other tissues. In the brain, alpha-synuclein is found mainly at the tips of nerve cells (neurons) in specialized structures called presynaptic terminals. Presynaptic terminals release chemical messengers, called neurotransmitters, from compartments known as synaptic vesicles. The release of neurotransmitters relays signals between neurons and is critical for normal brain function.

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Low ferritin levels and iron deficiencies may be found in PANS patients.

8/22/2020

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Pediatric acute-onset neuropsychiatric syndrome (PANS) is a complex neurological disorder that more scientists are studying in order to learn more about the origins of this illness that along with PANDAS (pediatric autoimmune neuropsychiatric disorders associate with streptococcal infections) is estimated to affect 1 in 200 children.

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The APOE gene and its role in cognitive decline.

7/23/2020

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Cognitive dysfunction is a very common symptom even in newly diagnosed multiple sclerosis patients as well as in other neurodegenerative disorders. Much research, including a recent study that we will discuss later in this article, has been conducted regarding the APOE gene locus as a possible mediator of cognitive impairment and its association with dementias such as Alzheimer’s disease.

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Social defeat and the brain: new study reveals additional effects of stress.

5/26/2020

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We’ve long known that stress has negative consequences in regard to our health and is especially deleterious for our brains. Findings from a recently published study now point to the impact of additional effects as it relates to chronic stress or “social defeat,” which is a concept used in the study of the physiological and behavioral effects of hostile interactions among subjects (that can be animal or human models).
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Modafinil goes well beyond addressing fatigue.

4/27/2020

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One of the most common complaints in all patients with autoimmune disease is chronic fatigue. Modafinil is a psychostimulant drug that was approved in 1998 by the Food and Drug Administration (FDA) for the treatment of narcolepsy, excessive daytime sleepiness and obstructive sleep apnea.
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This medication is also commonly prescribed off label for chronic fatigue, ADHD, mood boosting and cognitive enhancement.

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COVID-19 news: could the virus also affect the nervous system?

4/2/2020

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Coronavirus (CoV) is an enveloped virus with a large positive-sense, single-stranded RNA genome belonging to the Coronaviridae family; examples of CoV are SARS, MERS and now COVID-19.

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Low levels of IgG in MS patients.

1/24/2020

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This recent study showed that patients with multiple sclerosis (MS) have reduced IgG levels, while prior studies also showed a link to other types of autoimmune diseases and similar low IgG levels. We need to ask why this matters and why does this occur? And just as important, what can we do with this new information to positively impact our treatment approaches? 


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Mold is bad news for the brain.

1/19/2020

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In a recent journal published in Brain, Behavior and Immunity* we can truly see how mold is bad news for the brain. In this study they dripped Stachybotrys fungi into the nose of rats   (can’t imagine having this job!) and found within a short period of time hippocampal immune activation, decreased memory and striking anxiety and as well reduced levels of dopamine .   


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Minocycline Trial for Alzheimer’s disease yields disappointing results.

1/3/2020

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Update, July 2020…re: new information about minocycline.
Interesting new research has come to light since we last wrote about minocycline, a medication that has been around for quite some time (actually, about 50 years!) and is commonly prescribed to treat bacterial infections.

As previously discussed in our first blog that follows here, the dosage used in the Alzheimer’s disease trials was 200-400mg per day, but not many patients were able to tolerate this for very long due to gastrointestinal side effects.

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Neuro-degenerative Disease and Toxins

11/1/2019

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I recently was asked to consult on a case of a set designer with multiple years on Broadway who developed Multiple System Atrophy (MSA) in his early 50s. Within five years, he was no longer able to live independently.  
MSA is such a horrid disease. Characterized by younger onset, atypical Polycystic Kidney Disease (PKD), bad gait, ataxia, dysarthria, cerebellar strokes and autonomic failure, the slow and awful progression of MSA - like many others - indicates strong genetic linkage disequilibrium.


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The Importance of the Microbiome in Multiple Sclerosis

10/15/2019

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In the new study “Multiple Sclerosis: Possibility of a Gut Environment-Induced Disease,” research once again outlines the importance of the status of the gut (microbiome) in health and wellness both for those who want to take a preventative approach, and also for those who are already on the road to disease.
 
The study focused on several key findings:


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    by Suzanne Gazda M.D.
    Here you’ll find a collection of articles and information from a more-scientific perspective about many aspects of the neurological conditions we treat at Gazda Integrative Neurology.
    Please check back often as new items are regularly added.

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  • Home
  • Meet Dr. Gazda
    • Our Practice
  • BLOGS
    • Blog - Long Covid
    • Blog - NEUROLOGY TRENDS
    • Blog - MS in the NEWS
    • Blog - Scientifically Speaking
    • Blog - Guest Articles
  • Our Approach
  • Conditions we treat
    • Alzheimer’s Disease
    • Amyotrophic Lateral Sclerosis (ALS)
    • Long COVID
    • Multiple Sclerosis (MS)
    • PANS | PANDAS
    • Parkinson’s disease
  • Treatment Protocols
  • Patient Stories
  • FAQ
  • Policies & Rates
  • Helpful LInks
  • Medical Resources
  • Journal Articles
  • Product Recommendations
  • Become a Patient
  • NEWS
  • Contact