The superantigen theory of long COVID and added neurotoxin.

PART 5: The long COVID tsunami – what are the neurological implications?

What could be causing this puzzling war on the brain in the absence of viral infection?  As we go through this blog series, we will explore why the Brain is being battered in Long Covid.  

In this article published in Frontiers of Immunology (July 2022), “Multisystem Inflammatory Syndrome in Children and Long COVID: The SARS-CoV-2 Viral Superantigen Hypothesis,” revealed some incredibly shocking findings. In the spike protein motif, a viral super antigen complex and neurotoxin were found.
 
The authors propose that in the context of an intense antiviral immune response, inefficient viral clearance associated with SARS-CoV-2 (spike) persistence and repeated viral exposure may lead to uncontrolled and maladapted immune responses that cross-react with autoantigens leading to autoimmune disease.
 
As for the neurotoxin, the portion (Y674QTQTNSPRRAR685) of the SAg-like motif (E661-R685) homologous to alpha-neurotoxin motifs from snake venom. The identification of these neurotoxin motifs in SARS-CoV-2 raises the possibility that spike may also have direct neurotoxic activity and contribute to the neurological symptoms. 

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